Zepbound Dosage Chart 2026
Complete Zepbound titration schedule from 2.5mg to 15mg, plus how to access affordable compounded tirzepatide through Coreage Rx.
What Is Zepbound?
Quick Facts:
- Active Ingredient: Tirzepatide
- FDA-Approved For: Chronic weight management in adults with obesity or overweight with weight-related conditions
- Medication Type: GLP-1/GIP receptor agonist (dual-action)
- Administration: Once-weekly subcutaneous injection
- Manufacturer: Eli Lilly
- Same Active Ingredient As: Mounjaro (diabetes version)
Zepbound is a prescription weight loss medication that works by mimicking two natural hormones (GLP-1 and GIP) that regulate appetite and blood sugar. Clinical trials showed patients lost an average of 15-21% of their body weight over 72 weeks.
Complete Zepbound Dosage Chart
The FDA-approved titration schedule gradually increases your dose to minimize side effects while maximizing weight loss results.
| Week/Month | Dosage | Purpose |
|---|---|---|
| Weeks 1-4 | 2.5 mg | Starting dose. Allows your body to adjust to the medication and minimizes initial side effects like nausea. |
| Weeks 5-8 | 5 mg | First increase. Most people begin seeing noticeable appetite suppression and initial weight loss at this dose. |
| Weeks 9-12 | 7.5 mg | Second increase. Enhanced weight loss effects. Some patients stay at this maintenance dose. |
| Weeks 13-16 | 10 mg | Third increase. Stronger appetite control and weight loss acceleration. |
| Weeks 17-20 | 12.5 mg | Fourth increase. Near-maximum dosing for significant weight loss. |
| Week 21+ | 15 mg | Maximum dose. Highest FDA-approved dose for maximum weight loss effects. Maintenance dose for most patients. |
⚠️ Important Dosing Notes
- Each dose increase should occur after at least 4 weeks on the previous dose
- Your doctor may delay dose increases if you experience significant side effects
- Some patients achieve their goals at lower doses (7.5mg or 10mg) and don't need to reach 15mg
- Never skip doses or increase faster than recommended—this increases side effect risk
- Inject once weekly on the same day each week, any time of day
- Can be injected in abdomen, thigh, or upper arm
Get Compounded Tirzepatide Through Coreage Rx
Why pay $1,000+ per month for brand-name Zepbound when you can get the same active ingredient for a fraction of the cost?
Zepbound vs Compounded Tirzepatide (Coreage Rx)
| Factor | Zepbound (Brand) | Coreage Rx (Compounded) ⭐ |
|---|---|---|
| Active Ingredient | Tirzepatide | Tirzepatide |
| Monthly Cost (No Insurance) | $1,000-1,200 | 50-70% Less |
| Physician Supervision | ✓ | ✓ |
| Dosing Protocol | Same titration | Same titration |
| Availability | Frequent shortages | More Available |
| Telehealth Option | Varies | 100% Online |
| Weight Loss Results | 15-21% body weight | 15-21% body weight |
Massive Savings
Pay 50-70% less than brand-name Zepbound while getting the same active ingredient (tirzepatide) and results.
Full Medical Support
US board-certified physicians prescribe, monitor, and adjust your tirzepatide dosing following the same FDA-approved protocol.
Fast & Easy
Complete online assessment, get approved within 24 hours, medication shipped to your door. No insurance battles.
My Experience with Compounded Tirzepatide
When my doctor recommended Zepbound, I was excited—until I saw the $1,200/month price tag. My insurance wouldn't cover it for weight loss. That's when I discovered Coreage Rx's compounded tirzepatide program.
I followed the exact same dosing schedule shown above (started at 2.5mg, now at 10mg). The appetite suppression was powerful from week 1. By week 8 on the 5mg dose, I'd lost 12 pounds. At week 16 on 10mg, I'm down 16 pounds total.
Same active ingredient, same dosing protocol, same results—at a price I can actually afford.
Managing Side Effects During Titration
The gradual dosing schedule minimizes side effects, but some people still experience them—especially during dose increases. Here's how to manage the most common ones:
🤢 Nausea & Digestive Issues
Most common, especially in first 2-3 days after dose increase.
- Eat smaller, more frequent meals instead of large meals
- Avoid fatty, greasy, or spicy foods
- Stay hydrated—sip water throughout the day
- Eat slowly and stop when satisfied (not overly full)
- Ginger tea or crackers can help settle your stomach
💩 Constipation or Diarrhea
GI changes are common as medication slows digestion.
- Increase fiber intake (fruits, vegetables, whole grains)
- Drink plenty of water (8+ glasses daily)
- Light exercise helps stimulate digestion
- Over-the-counter fiber supplements if needed
- Talk to your doctor if severe or persistent
😴 Fatigue
Some people feel tired, especially when eating significantly less.
- Ensure you're eating enough protein and nutrients
- Don't skip meals even if you're not hungry
- Prioritize sleep (7-9 hours nightly)
- Light to moderate exercise can actually boost energy
- Consider a multivitamin to prevent deficiencies
⚠️ When to Contact Your Doctor
Seek medical attention if you experience:
- Severe abdominal pain that won't go away
- Persistent vomiting or inability to keep food/liquids down
- Signs of pancreatitis (severe upper stomach pain radiating to back)
- Vision changes
- Rapid heartbeat or chest pain
- Signs of allergic reaction (rash, swelling, difficulty breathing)
- Severe or worsening side effects that don't improve
Frequently Asked Questions
Can I stay at a lower dose if I'm getting good results?
Yes! Many people achieve their weight loss goals at 7.5mg or 10mg and don't need to increase to the maximum 15mg dose. Work with your physician to find the lowest effective dose that gives you results with minimal side effects.
What if I miss a dose?
If you miss a dose and it's been less than 4 days since your scheduled injection, take it as soon as you remember. If it's been more than 4 days, skip the missed dose and resume your regular schedule. Don't double up on doses.
How much does Zepbound cost?
Brand-name Zepbound costs $1,000-1,200 per month without insurance. Most insurance plans don't cover it for weight loss. Compounded tirzepatide through services like Coreage Rx costs 50-70% less while containing the same active ingredient.
What's the difference between Zepbound and Mounjaro?
Both contain the same active ingredient (tirzepatide) and use the same dosing schedule. Mounjaro is FDA-approved for type 2 diabetes, while Zepbound is FDA-approved for chronic weight management. They're essentially the same medication for different approved uses.
How long do I need to take Zepbound?
Zepbound is intended for long-term chronic weight management. Most people need to continue treatment indefinitely to maintain weight loss. Stopping the medication often results in weight regain. This is a lifestyle medication, not a short-term fix.
Can I increase my dose faster than the schedule?
No. Never increase your dose faster than recommended by your physician. The 4-week intervals between dose increases are designed to minimize side effects and allow your body to adjust. Increasing too quickly significantly raises the risk of nausea, vomiting, and other adverse effects.
Get Tirzepatide at an Affordable Price
Skip the $1,200/month brand-name price. Get physician-supervised compounded tirzepatide through Coreage Rx at a fraction of the cost.
Partnership Disclosure: The link below is an affiliate link. If you sign up through this link, we may receive compensation from Coreage Rx at no additional cost to you. This helps support our website and honest reviews.
Consultation with a licensed physician required. Not all applicants will qualify for treatment. Individual results may vary. This is a prescription medication program with potential risks and side effects.
⚠️ Important Medical Information
This article is for informational purposes only and does not constitute medical advice. Zepbound (tirzepatide) is a prescription-only medication that requires physician consultation and supervision.
Tirzepatide can cause serious side effects including pancreatitis, gallbladder problems, thyroid tumors (in animal studies), kidney problems, vision changes, and severe gastrointestinal issues. Not all patients qualify for treatment.
Always follow your physician's dosing instructions exactly. Never adjust doses without medical supervision.
Read the full Medical Disclaimer and Affiliate Disclosure.