New and Emerging Weight Loss Drugs
The next generation of obesity medications is reaching 24-30% weight loss in trials, and the pace of development has not slowed. This hub covers every major pipeline drug with the actual trial data, honest timelines, and a consistent warning: none of these are available yet, and gray-market versions are dangerous.
6 guides in this topic · Last updated August 3, 2026
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MAIN GUIDERetatrutide: The Triple Agonist Hitting 30% Weight Loss
TRIUMPH-1 data on retatrutide, the GLP-1/GIP/glucagon triple agonist producing up to 30.3% weight loss. How it works, approval status, side effects, and why gray-market versions are dangerous.
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Amycretin: 24% Weight Loss From GLP-1 + Amylin
Novo Nordisk's GLP-1 and amylin co-agonist reached 24% weight loss in just 36 weeks, with both injectable and oral versions advancing to Phase 3. Lancet trial data, mechanism, and timeline.
MariTide: The Once-Monthly Obesity Shot
Amgen's monthly injection reached ~20% weight loss at 52 weeks with no plateau. NEJM Phase 2 data, the unusual GIP-blocking mechanism, and why 12 injections a year could change adherence.
CagriSema: The Most Powerful Weight Loss Drug Yet?
CagriSema combines cagrilintide + semaglutide for up to 25% weight loss. Clinical trial results, how it works, expected approval timeline, and how it compares to existing GLP-1s.
Survodutide for Weight Loss: New GLP-1/Glucagon Drug
Everything about survodutide, the new dual GLP-1/glucagon receptor agonist showing up to 19% weight loss in trials. How it compares to semaglutide and tirzepatide.
When Will Semaglutide Go Generic?
Canada already has generic semaglutide after Novo Nordisk's patent lapsed. Country-by-country patent timeline, why the US waits until the 2030s, and how cheap generics will realistically be.
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