Semaglutide Dosage Chart: Complete Titration Schedule
Starting semaglutide (Ozempic, Wegovy, or compounded)? Here's the complete dosage chart showing the standard titration schedule, when to increase your dose, how to manage side effects, and what to expect at each level.
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Quick Answer
The standard semaglutide dosage chart starts at 0.25mg weekly for the first month, then increases every 4 weeks: 0.5mg → 1mg → 1.7mg → 2mg (Ozempic) or 2.4mg (Wegovy). This gradual titration minimizes side effects while maximizing weight loss.
Key point: You stay at each dose for a minimum of 4 weeks to allow your body to adjust. Never skip doses or increase faster than recommended—the slow titration is essential for tolerating the medication.
Complete Semaglutide Dosage Chart
| Timeframe | Dose | Purpose | Expected Results |
|---|---|---|---|
| Weeks 1-4 | 0.25mg | Initiation dose | Minimal weight loss, body adjusting |
| Weeks 5-8 | 0.5mg | First therapeutic dose | Noticeable appetite reduction, 1-2 lbs/week |
| Weeks 9-12 | 1mg | Standard maintenance dose | Significant appetite suppression, 1-2 lbs/week |
| Weeks 13-16 | 1.7mg | Higher therapeutic dose | Strong appetite control, consistent weight loss |
| Week 17+ | 2mg (Ozempic max) | Maximum diabetes dose | Peak diabetes control, good weight loss |
| Week 17-20 | 2.4mg (Wegovy max) | Maximum weight loss dose | Maximum appetite suppression and weight loss |
Important Notes:
- • Ozempic: FDA-approved for diabetes, max dose 2mg (often used off-label for weight loss)
- • Wegovy: FDA-approved for weight loss, max dose 2.4mg
- • Compounded semaglutide: Follows same dosing schedule, costs significantly less
- • You inject once weekly on the same day each week
- • Stay at each dose minimum 4 weeks before increasing
What to Expect at Each Dose
0.25mg (Weeks 1-4): The Starter Dose
Purpose: This is NOT a therapeutic dose—it's purely for your body to adjust to the medication.
What you'll feel:
- • Mild appetite reduction (not dramatic)
- • Possible mild nausea (usually temporary)
- • Minimal to no weight loss (1-3 lbs max)
My experience: I felt almost nothing at 0.25mg. Slight decrease in appetite, no nausea, lost 2 lbs (probably water weight). Don't be discouraged—this dose is just preparing your body.
0.5mg (Weeks 5-8): First Real Effects
Purpose: This is where most people start noticing real appetite suppression.
What you'll feel:
- • Noticeable reduction in hunger
- • Food portions naturally decrease
- • Possible nausea after eating too much
- • Weight loss 1-2 lbs per week
My experience: This is when I knew the medication was working. I'd forget to eat lunch. Portions that used to satisfy me felt like too much. Lost 5 lbs over 4 weeks.
1mg (Weeks 9-12): The Sweet Spot
Purpose: Many people stay at 1mg long-term. It's effective for both diabetes and weight loss.
What you'll feel:
- • Strong appetite control
- • Eating 40-50% less than before medication
- • Food thoughts significantly reduced
- • Consistent 1-2 lbs/week weight loss
My experience: At 1mg, I felt like I had a "normal" relationship with food for the first time in years. Not obsessing about my next meal. Very satisfied with small portions.
1.7mg (Weeks 13-16): Higher Dose
Purpose: For people who need more appetite suppression or hit a plateau at 1mg.
What you'll feel:
- • Even stronger appetite suppression
- • May need to force yourself to eat enough protein
- • Side effects may be slightly more pronounced
- • Continued steady weight loss
Note: Some people stay at 1mg if it's working well. Only increase to 1.7mg if weight loss stalls or hunger returns.
2mg-2.4mg (Week 17+): Maximum Dose
Purpose: 2mg is Ozempic max, 2.4mg is Wegovy max. Provides maximum weight loss effect.
What you'll feel:
- • Peak appetite suppression
- • Must be intentional about eating enough
- • Nausea more likely if you overeat
- • Maximum weight loss potential
Important: Not everyone needs or tolerates the maximum dose. Many people achieve excellent results at 1mg or 1.7mg. Work with your doctor to find your optimal dose.
When (and When Not) to Increase Your Dose
✅ Increase Your Dose If:
- ✓You've been at current dose for at least 4 weeks
- ✓Appetite suppression is wearing off
- ✓Weight loss has plateaued for 2+ weeks
- ✓Side effects are minimal or resolved
- ✓Your doctor approves the increase
⛔ DON'T Increase Your Dose If:
- ✗You've only been at current dose 1-3 weeks
- ✗You're still experiencing significant side effects
- ✗You're losing weight too rapidly (3+ lbs/week)
- ✗Current dose is working well
- ✗You're struggling to eat enough protein
My Titration Timeline:
- • 0.25mg (4 weeks): Minimal effects, 2 lbs lost
- • 0.5mg (4 weeks): Real appetite suppression began, 5 lbs lost
- • 1mg (8 weeks): Perfect dose for me. Stayed here longer. 9 lbs lost
- • Current: Still at 1mg after 10 weeks. Total weight loss: 16 lbs
I haven't increased to 1.7mg yet because 1mg is working beautifully. My doctor and I agreed to stay here as long as I'm losing 1-2 lbs/week consistently.
Managing Side Effects During Titration
Side effects are usually worst in the first 2-3 days after each dose increase, then improve. Here's how to manage them:
Nausea
- • Eat smaller, more frequent meals (5-6 small meals vs 3 large)
- • Avoid greasy, fatty, or spicy foods
- • Eat slowly and stop when satisfied (not full)
- • Ginger tea or ginger candies can help
- • Take anti-nausea medication if prescribed
Constipation
- • Drink 64-80 oz water daily
- • Increase fiber gradually (vegetables, fruits, whole grains)
- • Daily movement (even just walking helps)
- • Consider a gentle stool softener if needed
Fatigue
- • Ensure you're eating enough calories (minimum 1,200/day)
- • Prioritize protein (0.7-1g per pound body weight)
- • Stay hydrated
- • Get 7-9 hours sleep
- • Consider reducing dose if severe
Acid Reflux/Heartburn
- • Avoid eating 2-3 hours before bed
- • Reduce acidic foods (tomatoes, citrus, coffee)
- • Elevate head of bed if nighttime symptoms
- • Over-the-counter antacids as needed
Important: Most side effects improve after 2-4 weeks at each dose level. If they don't, or if they're severe, talk to your doctor about staying at your current dose longer or reducing temporarily.
Get Physician-Supervised Semaglutide Treatment
Proper dosing and titration require physician oversight. This is why I use Coreage Rx—they provide medical supervision, help you find your optimal dose, and adjust your protocol if you experience side effects.
Coreage Rx - #1 Recommended
Physician-supervised semaglutide with personalized titration schedule and ongoing dosing support.
$99/month: Compounded semaglutide (same active ingredient as Ozempic/Wegovy)
93% less expensive than brand-name Ozempic ($900/month) or Wegovy ($1,400/month)
- ✓Doctor consultation to determine starting dose
- ✓Flexible titration based on your tolerance
- ✓Dose adjustments if you experience side effects
- ✓Monthly medication delivered to your door
- ✓Ongoing medical support throughout your journey
Physician supervision ensures you titrate safely, manage side effects effectively, and find the optimal dose for your individual needs.
The Bottom Line
The standard semaglutide dosage chart follows a careful titration schedule: 0.25mg (4 weeks) → 0.5mg (4 weeks) → 1mg (4+ weeks) → 1.7mg (optional) → 2mg-2.4mg (maximum).
Key Takeaways:
- • Start low, go slow: The gradual increase prevents severe side effects
- • Stay at each dose 4+ weeks: Your body needs time to adjust
- • 1mg is the sweet spot for many: Effective weight loss with manageable side effects
- • Maximum dose isn't always necessary: Stay at your effective dose
- • Side effects are usually temporary: They improve after 2-4 weeks at each level
- • Work with your doctor: Adjust titration based on your response
Remember: This is a marathon, not a sprint. The slow titration schedule exists for a reason—it helps you tolerate the medication long-term, which is what actually leads to sustained weight loss. Rushing through doses or skipping levels increases side effects and dropout rates.
Find your optimal dose—the one where you get good appetite suppression and weight loss without intolerable side effects—and stay there as long as it's working.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Semaglutide dosing should only be determined and adjusted by a qualified healthcare provider. Never change your dose without consulting your doctor. Individual dosing needs vary based on medical history, tolerance, and treatment goals.