Celebrities on Weight Loss Drugs

The complete guide to celebrities using GLP-1 medications like Ozempic, Wegovy, and Mounjaro. Who's admitted it? Who's denying it? And how can regular people access these same medications affordably?

By ClarisseUpdated January 2026

The Hollywood Weight Loss Secret

If you've noticed your favorite celebrities looking dramatically slimmer lately, you're not imagining it. Hollywood has embraced GLP-1 weight loss medications—originally designed for diabetes—as the new go-to solution for rapid weight loss.

These medications include Ozempic (semaglutide), Wegovy (higher-dose semaglutide), Mounjaro (tirzepatide), and Zepbound (tirzepatide for weight loss). They work by suppressing appetite, slowing digestion, and helping people lose 15-20% of their body weight.

Why Celebrities Love GLP-1 Drugs

  • Dramatic results: 15-20% body weight loss in months
  • Minimal effort: Once-weekly injection suppresses appetite naturally
  • Fast transformation: Prepare for roles or red carpet events quickly
  • Medical legitimacy: FDA-approved with physician supervision
  • Discreet: Can be done privately without public gym sessions
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Celebrities Who've Admitted Using Weight Loss Drugs

Elon Musk

Medication: Wegovy (semaglutide)

The Tesla CEO openly tweeted about using Wegovy for weight loss, crediting it for his slimmer appearance. He's one of the few high-profile figures to publicly acknowledge using GLP-1 medications without shame.

Amy Schumer

Medication: Ozempic (semaglutide)

Comedian Amy Schumer revealed she tried Ozempic but stopped due to severe side effects. She was candid about the medication making her "so sick" that she couldn't function or take care of her son.

Chelsea Handler

Medication: Ozempic (semaglutide)

Talk show host Chelsea Handler admitted her doctor prescribed Ozempic without her realizing what it was. She stopped taking it after learning about its effects and the trend in Hollywood.

Sharon Osbourne

Medication: Ozempic (semaglutide)

Sharon Osbourne publicly discussed using Ozempic and losing significant weight, though she later expressed concerns about losing "too much" weight and warned others about potential over-use.

Oprah Winfrey

Medication: Unspecified GLP-1 medication

In late 2023, Oprah publicly acknowledged using a weight loss medication as a "tool" alongside diet and exercise. While she didn't name the specific drug, it's widely believed to be a GLP-1 medication like Wegovy or Mounjaro.

Rebel Wilson

Medication: Likely Ozempic or Wegovy (unconfirmed)

Rebel Wilson's dramatic 80-pound weight loss led to speculation about GLP-1 use, though she attributes it to diet, exercise, and "Year of Health." Many suspect medication played a role given the rapid timeline and Hollywood trends.

Celebrities Speculated to Be Using GLP-1s

Note: The following celebrities have not confirmed using weight loss medications, but their dramatic transformations have sparked widespread speculation in media and among fans.

Kim Kardashian

Her rapid weight loss for the 2022 Met Gala sparked intense speculation about Ozempic use, though she's denied it and credits strict diet and exercise.

Khloe Kardashian

Dramatic and sustained weight loss has led to persistent rumors about GLP-1 medication use, though she's repeatedly denied these claims.

Kyle Richards

The Real Housewives star's noticeable weight loss led to Ozempic speculation, which she's firmly denied while discussing her fitness routine.

Jessica Simpson

After losing 100 pounds post-pregnancy, speculation arose about GLP-1 use, though she's credited personal trainer sessions and strict diet.

Mindy Kaling

Her slim-down sparked Ozempic rumors, which she addressed by saying she worked hard on diet and exercise, though the speculation continues.

Why the Secrecy Around Weight Loss Drugs?

Despite GLP-1 medications being FDA-approved and medically legitimate, most celebrities won't admit using them. Here's why:

  • Public pressure to appear "natural": Fans want to believe celebrity bodies are achievable through willpower alone
  • Brand image concerns: Fitness influencers and wellness brands can't admit to pharmaceutical help
  • Stigma around medication: Weight loss drugs still carry shame, unlike cosmetic procedures
  • Concerns about diabetes patients: Media criticism about using diabetes medication for vanity
  • Privacy: Medical information is personal, even for public figures

The irony? Celebrities will openly discuss Botox, fillers, facelifts, and even surgeries—but GLP-1 medications remain taboo to acknowledge.

Frequently Asked Questions

Are celebrities using actual Ozempic or compounded versions?

Most celebrities with expensive concierge doctors likely use brand-name Ozempic, Wegovy, or Mounjaro since cost isn't a barrier. However, regular people increasingly use compounded semaglutide or tirzepatide from services like Coreage Rx—same active ingredient, dramatically lower cost.

How much weight can you lose on these medications?

Clinical trials show average weight loss of 15-20% of body weight over 6-12 months on Wegovy or Mounjaro. That's 30-40 pounds for someone weighing 200 pounds. Individual results vary based on diet, exercise, and dosing.

Can regular people get the same medications as celebrities?

Yes! You don't need celebrity connections. Telehealth services like Coreage Rx offer physician-supervised GLP-1 treatment with compounded semaglutide or tirzepatide at 50-70% lower cost than brand-name versions. Same medications, same results, affordable pricing.

Why do some celebrities stop taking these drugs?

Side effects are the main reason. Nausea, vomiting, fatigue, and digestive issues can be severe for some people. Additionally, some lose "too much" weight or experience "Ozempic face" (facial volume loss). Always use under medical supervision.

Are these drugs safe for non-diabetics?

Yes, when prescribed by a physician. Wegovy and Zepbound are FDA-approved specifically for weight loss in non-diabetic people with obesity or overweight with health conditions. Ozempic and Mounjaro are diabetes medications but contain the same active ingredients. Medical supervision is essential.

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⚠️ Important Disclaimer

This article discusses publicly reported celebrity use of weight loss medications. Claims about specific celebrities are based on their own statements or widespread media reports.

Weight loss medications should only be used under medical supervision. Always consult a qualified healthcare provider before starting any prescription medication.

Read the full Medical Disclaimer.

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