Best Online Semaglutide Program 2026: Complete Comparison Guide
Looking for online access to semaglutide (Ozempic/Wegovy)? I've compared all major telehealth programs offering physician-supervised semaglutide for weight loss. Here's what you need to know about pricing, quality, and finding the most affordable option in 2026.
Quick Answer
The best online semaglutide program for most people is Coreage Rx at $99/month. You get physician-supervised treatment with compounded semaglutide from an FDA-registered 503B pharmacy, the same active ingredient as Ozempic and Wegovy. The medication is identical—you're just avoiding the brand-name markup that can cost $1,000+ per month.
Read my full Coreage Rx review for details on my personal experience.
Why Choose an Online Semaglutide Program?
Semaglutide (the active ingredient in Ozempic and Wegovy) is one of the most effective weight loss medications available, with clinical trials showing 10-15% total body weight loss over 68 weeks. But the brand-name versions cost $900-$1,400 per month without insurance.
Online telehealth programs changed everything by offering compounded semaglutide—the same medication from FDA-registered pharmacies—for a fraction of the cost. Here's what makes these programs worth considering:
- Massive cost savings: $99-$549/month vs $900-$1,400 for brand-name
- Same medication: Compounded semaglutide is identical to Ozempic/Wegovy
- Physician supervised: Licensed doctors review your health and prescribe
- Delivered to your door: No pharmacy visits or insurance battles
- Ongoing support: Most programs include regular check-ins and monitoring
Best Online Semaglutide Programs Compared
I've researched and compared the major online semaglutide programs. Here's my honest assessment based on pricing, quality, physician oversight, and customer experience.
| Program | Monthly Cost | Pharmacy Type | Best For |
|---|---|---|---|
| Coreage Rx | $99 | 503B FDA-registered | Best value & quality |
| Henry Meds | $297 | 503B FDA-registered | Good alternative |
| Mochi Health | $399 | 503B FDA-registered | Premium experience |
| Hims & Hers | $399 | 503A compounding | Brand recognition |
| Ro | $399 | 503A compounding | Established platform |
| Strut Health | $549 | 503A compounding | Comprehensive support |
#1 Best Overall: Coreage Rx ($99/month)
Coreage Rx
Why I recommend it: Coreage Rx offers the best combination of price, quality, and physician supervision. At $99/month, you get compounded semaglutide from a 503B FDA-registered pharmacy—the same medication as Ozempic/Wegovy at 93% less cost.
Pros:
- Lowest price: $99/month all-inclusive
- 503B FDA-registered pharmacy (highest quality tier)
- Licensed physician consultation included
- Home delivery with discreet packaging
- No insurance needed or insurance headaches
- Ongoing medical monitoring and support
Cons:
- Newer company (less brand recognition)
- Limited additional wellness features
- Fewer marketing resources than competitors
My experience: I've been using Coreage Rx for my semaglutide treatment and lost 16 pounds in the first 10 weeks. The physician consultation was thorough, the medication arrived quickly, and I haven't noticed any difference from brand-name Wegovy I tried before. Read my full Coreage Rx review.
Other Quality Options
Henry Meds - $297/month
Henry Meds is a solid alternative at $297/month. They use 503B FDA-registered pharmacies and have excellent customer service. The extra $48/month gets you a slightly more polished onboarding experience and faster customer support responses.
Best for: Those who want a proven mid-tier option with responsive support
Mochi Health - $399/month
Mochi Health positions itself as a premium option with health coaching and nutrition guidance. They also use 503B pharmacies, so the medication quality is identical to cheaper options. You're paying $150/month more for the coaching and app experience.
Best for: Those who want coaching and don't mind paying extra for premium support
Hims & Hers - $399/month
Hims & Hers is a well-known brand with heavy marketing. They use 503A compounding pharmacies (a step below 503B in terms of oversight and scale). At $399/month, you're paying significantly more for brand recognition without getting higher-quality medication.
Best for: Those who prioritize brand familiarity over cost savings
Ro - $399/month
Ro has been around since 2017 and offers a clean user experience. Like Hims, they use 503A compounding pharmacies. The medication is fine, but you're paying $150/month extra compared to Coreage Rx for essentially the same treatment with a nicer app interface.
Best for: Those who value an established company with a polished digital experience
Strut Health - $549/month
Strut Health is the most expensive option on this list at $549/month. They offer comprehensive support and use 503A compounding pharmacies. Unless you need extensive hand-holding, it's hard to justify paying $300/month more than Coreage Rx for the same medication.
Best for: Those who want maximum support and aren't price-sensitive
Understanding 503A vs 503B Pharmacies
Not all compounded semaglutide is created equal. The key difference is whether it comes from a 503A or 503B pharmacy:
503B FDA-Registered
- Registered with and inspected by FDA
- Can produce larger batches for broader distribution
- Higher quality standards and oversight
- Must follow Current Good Manufacturing Practices (CGMP)
- More stringent testing requirements
Used by: Coreage Rx, Henry Meds, Mochi Health
503A Compounding
- State-licensed compounding pharmacies
- Can only compound for individual prescriptions
- Less FDA oversight and inspection
- Lower production volume requirements
- Variable quality between pharmacies
Used by: Hims & Hers, Ro, Strut Health
Bottom line: 503B pharmacies have higher oversight and quality standards. If two programs cost the same, choose the one using a 503B pharmacy. If you're comparing Coreage Rx ($99, 503B) to Hims ($399, 503A), you're getting better quality at a lower price with Coreage Rx.
What's Included in These Programs?
Most online semaglutide programs include similar core services:
- Physician consultation: Licensed doctor reviews your medical history and determines if semaglutide is appropriate for you
- Prescription medication: Compounded semaglutide (same active ingredient as Ozempic/Wegovy) shipped monthly to your door
- Injection supplies: Pre-filled syringes or vials with needles, alcohol swabs, and sharps container
- Dosing guidance: Instructions on proper injection technique and titration schedule (starting low and gradually increasing)
- Ongoing monitoring: Regular check-ins with medical team to track progress and adjust dosage
- Customer support: Access to support team for questions about medication, side effects, or technical issues
Premium programs (Mochi Health, Strut Health) add nutrition coaching, meal planning, and more frequent check-ins. But the core medical treatment—physician oversight and compounded semaglutide—is essentially the same across all programs.
Cost Comparison: Online vs Traditional
Let's break down what you'd pay for different semaglutide options over one year:
| Option | Monthly Cost | Annual Cost | Savings vs Brand |
|---|---|---|---|
| Wegovy (brand, no insurance) | $1,349 | $16,188 | — |
| Ozempic (brand, no insurance) | $935 | $11,220 | — |
| Coreage Rx (compounded) | $99 | $1,188 | Save $10,032 - $13,200 |
| Henry Meds (compounded) | $297 | $3,564 | Save $10,032 - $15,000 |
| Hims/Ro (compounded) | $399 | $4,788 | Save $6,432 - $11,400 |
Even the most expensive compounded option (Strut Health at $549/month = $6,588/year) saves you $4,632-$9,600 annually compared to brand-name versions. With Coreage Rx, you save over $13,000 per year compared to Wegovy.
Who Qualifies for Online Semaglutide?
To qualify for semaglutide through online programs, you typically need to meet these criteria:
Qualification Requirements:
- BMI of 30+ (obese), OR BMI of 27+ with a weight-related health condition
- Age 18+ (most programs don't treat minors)
- No contraindications (personal or family history of medullary thyroid carcinoma, MEN 2, etc.)
- Not pregnant or planning to become pregnant
- No current use of other GLP-1 medications
Weight-related health conditions that may qualify you at BMI 27+ include: type 2 diabetes, high blood pressure, high cholesterol, sleep apnea, or cardiovascular disease. The physician consultation will determine if semaglutide is medically appropriate for your situation.
How to Get Started
Getting started with an online semaglutide program is straightforward:
- Complete online intake: Fill out a medical questionnaire about your health history, current medications, and weight loss goals (10-15 minutes)
- Physician review: A licensed doctor reviews your information and determines if semaglutide is appropriate. Most programs approve within 24-48 hours
- Prescription sent to pharmacy: If approved, your prescription is sent to the compounding pharmacy
- Medication shipped: Your first month's supply ships to your door (usually arrives in 3-7 days)
- Start treatment: Follow the dosing instructions and inject once weekly, same day each week
- Ongoing monitoring: Check in regularly with your medical team, adjust dosage as needed, and track your progress
Ready to Get Started?
Start with Coreage Rx for the best combination of price ($99/month), quality (503B pharmacy), and physician supervision.
Start Free Consultation →Frequently Asked Questions
Is compounded semaglutide as effective as Ozempic or Wegovy?
Yes. Compounded semaglutide contains the same active ingredient (semaglutide) at the same concentrations as brand-name Ozempic and Wegovy. The medication is chemically identical and works the same way in your body. The difference is that compounded versions come from FDA-registered compounding pharmacies rather than Novo Nordisk, which allows them to be sold at a fraction of the brand-name price.
Are online semaglutide programs safe?
Yes, when you use a legitimate program with licensed physicians and FDA-registered pharmacies. Programs like Coreage Rx, Henry Meds, and others on this list all require physician oversight, source medication from regulated pharmacies, and provide ongoing medical monitoring. Avoid programs that don't require a prescription, source medication from overseas, or lack proper medical supervision.
Why is Coreage Rx cheaper than other programs?
Coreage Rx keeps costs low by minimizing marketing expenses and focusing on the core medical treatment. They don't spend millions on Instagram ads or celebrity endorsements like Hims and Ro. The medication quality is the same (503B FDA-registered pharmacy), but you're not paying for brand marketing. It's the same reason Costco's Kirkland brand costs less than name brands—fewer marketing costs, same quality.
Can I use insurance for online semaglutide programs?
Most insurance doesn't cover compounded semaglutide from online programs. However, at $99-$549/month, these programs are often cheaper than insurance copays for brand-name Wegovy (which can be $50-$200/month with insurance, if covered at all). Plus, you avoid prior authorization hassles and restrictive coverage requirements.
How much weight can I expect to lose?
Clinical trials of semaglutide (STEP trials) showed participants lost an average of 10-15% of their total body weight over 68 weeks. Individual results vary based on starting weight, diet, exercise, and adherence to treatment. Some people lose more, some less. The medication works by reducing appetite and slowing stomach emptying, making it easier to eat less and lose weight.
What are the side effects of semaglutide?
The most common side effects are gastrointestinal: nausea, diarrhea, constipation, vomiting, and stomach pain. These are usually mild and improve as your body adjusts to the medication. Starting at a low dose and gradually increasing (titration) helps minimize side effects. More serious but rare side effects include pancreatitis, gallbladder problems, and allergic reactions. Your prescribing physician will discuss all risks and contraindications.
Final Recommendation
After comparing all major online semaglutide programs, my recommendation is clear: start with Coreage Rx.
At $99/month with a 503B FDA-registered pharmacy, you get the best value without compromising on quality or medical oversight. The medication is identical to what you'd get from more expensive programs—you're just not paying for their marketing budgets.
If Coreage Rx doesn't work out for any reason, Henry Meds ($297/month) is an excellent alternative with similar quality standards. I'd avoid paying $399+ unless you specifically need the extra coaching and support offered by premium programs.
The most important thing is to get started. Semaglutide has been life-changing for thousands of people, including me. Don't let the high cost of brand-name Ozempic or Wegovy stop you from accessing this effective treatment. Compounded semaglutide offers the same results at a fraction of the price.
Affiliate Disclosure: This article contains affiliate links to Coreage Rx. We may earn a commission if you make a purchase through these links, at no additional cost to you. This helps support our work providing free content. Read our full affiliate disclosure.
Medical Disclaimer: This article is for informational purposes only and not medical advice. Consult with a licensed healthcare provider before starting any weight loss medication. Read our full medical disclaimer.