Best Compounding Pharmacy for Semaglutide 2026: Complete Comparison
Looking for affordable compounded semaglutide (Ozempic/Wegovy alternative)? I've compared all major compounding pharmacies to find the best combination of price, quality, and safety. Here's what you need to know about getting the same medication at a fraction of the brand-name cost.
Quick Answer
The best compounding pharmacy for semaglutide is Coreage Rx at $99/month. They use a 503B FDA-registered pharmacy that produces compounded semaglutide—chemically identical to Ozempic and Wegovy at 93% less cost. You get the same medication, same results, just without the brand-name markup.
Read my full Coreage Rx review for my personal experience.
Why Use a Compounding Pharmacy for Semaglutide?
Brand-name semaglutide (Ozempic and Wegovy) costs $900-$1,400 per month without insurance. Even with insurance, copays can be $50-$200/month, and many insurers won't cover these medications for weight loss.
Compounding pharmacies offer a solution: they produce semaglutide using the same active pharmaceutical ingredient at a fraction of the cost. Here's what you need to understand:
- Same active ingredient: Compounded semaglutide contains the exact same medication as Ozempic/Wegovy
- Same effectiveness: Clinical results are identical—compounding doesn't change how the drug works
- Massive savings: $99-$549/month vs $900-$1,400 for brand-name
- FDA-registered options: 503B pharmacies are FDA-registered and inspected
- Physician supervised: All legitimate compounding programs require a prescription from a licensed doctor
The difference in price doesn't reflect medication quality—it reflects the brand premium, marketing costs, and profit margins that pharmaceutical companies charge for Ozempic and Wegovy.
Best Compounding Pharmacies for Semaglutide Compared
I've researched all major options and compared them based on price, pharmacy type (503A vs 503B), physician oversight, and overall value. Here's my honest assessment:
| Pharmacy/Program | Monthly Cost | Pharmacy Type | Rating |
|---|---|---|---|
| Coreage Rx | $99 | 503B FDA-registered | ★★★★★ |
| Henry Meds | $297 | 503B FDA-registered | ★★★★☆ |
| Mochi Health | $399 | 503B FDA-registered | ★★★★☆ |
| Hims & Hers | $399 | 503A compounding | ★★★★☆ |
| Ro | $399 | 503A compounding | ★★★★☆ |
| Strut Health | $549 | 503A compounding | ★★★☆☆ |
#1 Best Value: Coreage Rx ($99/month)
Coreage Rx
Why this is my top pick: Coreage Rx offers the best combination of price and quality. At $99/month, you get compounded semaglutide from a 503B FDA-registered pharmacy—the highest tier of compounding oversight. You're getting premium quality at the lowest price.
Pros:
- Lowest price at $99/month all-inclusive
- 503B FDA-registered pharmacy (highest standards)
- Licensed physician consultation included
- Same medication as Ozempic/Wegovy
- Free shipping, discreet packaging
- Ongoing medical support and monitoring
- No insurance needed or hassles
Cons:
- Less brand recognition than Hims/Ro
- Newer company with less marketing
- Fewer additional features than premium options
My verdict: Unless you need extensive coaching or have money to burn, Coreage Rx is the clear best choice. The medication is identical to more expensive options, but you save $150-$300/month. Read my full Coreage Rx review.
Other Compounding Pharmacy Options
Henry Meds
$297/monthHenry Meds is a solid mid-tier option using 503B pharmacies. At $297/month, you're paying $48 more than Coreage Rx for essentially the same medication and service level. The extra cost gets you slightly faster customer support and a more polished onboarding experience, but the medication quality is identical.
Best for: Those who want a proven option and don't mind paying a bit more for faster support
Mochi Health
$399/monthMochi Health positions itself as a premium wellness platform with health coaching, nutrition guidance, and an app for tracking. They use 503B pharmacies, so the medication is identical to cheaper options. You're paying $150/month extra for the coaching and bells and whistles—worth it if you want that support, but not necessary for most people.
Best for: Those who want comprehensive coaching and aren't price-sensitive
Hims & Hers
$399/monthHims & Hers is a well-known brand with heavy advertising. They use 503A compounding pharmacies, which have less FDA oversight than 503B facilities. At $399/month, you're paying $150 more than Coreage Rx for lower-tier pharmacy oversight. You're essentially paying a premium for brand recognition without getting higher quality medication.
Best for: Those who prioritize brand familiarity over value and pharmacy quality
Ro
$399/monthRo (formerly Roman) has been around since 2017 and offers a polished user experience with a clean app interface. They use 503A compounding pharmacies like Hims. At $399/month, you're paying $150 extra compared to Coreage Rx for a nicer app and an established brand, but the same medication from a lower-tier pharmacy.
Best for: Those who value established companies and polished digital experiences
Strut Health
$549/monthStrut Health is the most expensive option at $549/month. They offer comprehensive support and frequent check-ins using 503A compounding pharmacies. Unless you need extensive hand-holding and have no budget constraints, it's hard to justify paying $300/month more than Coreage Rx for the same medication from a lower-tier pharmacy.
Best for: Those who want maximum support and cost is not a concern
503A vs 503B Pharmacies: What's the Difference?
This is crucial to understand when choosing a compounding pharmacy for semaglutide:
503B FDA-Registered ✓
HIGHER QUALITY TIER
- Registered with and inspected by FDA
- Can produce larger batches for distribution
- Must follow Current Good Manufacturing Practices (CGMP)
- More stringent testing and quality standards
- Higher oversight and accountability
- Required to report adverse events to FDA
✓ Used by: Coreage Rx, Henry Meds, Mochi Health
503A Compounding
LOWER QUALITY TIER
- State-licensed, not FDA-registered
- Can only compound individual prescriptions
- Less FDA oversight and inspection
- Not required to follow CGMP standards
- Variable quality between pharmacies
- Lower production and testing requirements
Used by: Hims & Hers, Ro, Strut Health
Key Takeaway:
503B pharmacies have higher quality standards and more FDA oversight. Coreage Rx ($99/month, 503B) offers better quality than Hims or Ro ($399/month, 503A) at a lower price. You're getting superior pharmacy oversight while saving $300/month.
Is Compounded Semaglutide Safe?
Yes, when sourced from legitimate compounding pharmacies with proper oversight. Here's what makes it safe:
- Same active ingredient: Compounded semaglutide uses the identical pharmaceutical-grade semaglutide as Ozempic and Wegovy
- FDA-registered facilities: 503B pharmacies are registered with and inspected by the FDA
- Physician oversight: All legitimate programs require a prescription from a licensed doctor who reviews your medical history
- Quality testing: Reputable compounding pharmacies test for purity, potency, and sterility
- Proven track record: Thousands of patients have safely used compounded semaglutide with results matching brand-name versions
⚠️ What to Avoid:
- Overseas pharmacies shipping from China, India, or other countries
- Programs that don't require a prescription or doctor consultation
- "Research chemical" semaglutide sold online without medical oversight
- Social media sellers offering semaglutide without proper licensing
- Prices that seem too good to be true (under $200/month is suspicious)
Annual Cost Comparison
Let's compare what you'll actually pay over one year for different semaglutide options:
| Option | Monthly | Annual | Annual Savings |
|---|---|---|---|
| Wegovy (brand, no insurance) | $1,349 | $16,188 | — |
| Ozempic (brand, no insurance) | $935 | $11,220 | — |
| Coreage Rx (503B compounded) | $99 | $1,188 | Save $10,032 - $13,200 |
| Henry Meds (503B compounded) | $297 | $3,564 | Save $10,032 - $15,000 |
| Hims/Ro (503A compounded) | $399 | $4,788 | Save $6,432 - $11,400 |
| Strut Health (503A compounded) | $549 | $6,588 | Save $4,632 - $9,600 |
With Coreage Rx, you save over $13,000 per year compared to brand-name Wegovy—enough for a nice vacation or to invest in your future.
How to Get Started
Getting compounded semaglutide through a reputable pharmacy is straightforward:
- Choose a program: I recommend starting with Coreage Rx for the best combination of price and quality
- Complete medical intake: Fill out a questionnaire about your health history, current medications, and weight loss goals (takes 10-15 minutes)
- Physician consultation: A licensed doctor reviews your information to determine if semaglutide is appropriate for you (approved within 24-48 hours typically)
- Prescription sent: If approved, your prescription is sent to the 503B compounding pharmacy
- Medication delivered: Your first month's supply ships to your door in discreet packaging (arrives in 3-7 days)
- Start treatment: Inject once weekly on the same day, starting with the lowest dose and gradually increasing as tolerated
Ready to Save $13,000/Year?
Get started with Coreage Rx for physician-supervised compounded semaglutide at $99/month—the same medication as Ozempic/Wegovy from a 503B FDA-registered pharmacy.
Start Free Consultation →Frequently Asked Questions
Is compounded semaglutide as effective as Ozempic or Wegovy?
Yes. Compounded semaglutide contains the exact same active pharmaceutical ingredient at the same concentrations. The medication works identically in your body—the only difference is who manufactures it (compounding pharmacy vs Novo Nordisk). Clinical results are the same: 10-15% average weight loss over 68 weeks.
Why is there such a huge price difference?
The price difference ($99 vs $1,349) doesn't reflect medication quality—it reflects Novo Nordisk's brand premium, research and development costs, marketing expenses, and profit margins. Compounding pharmacies can produce the same medication at a fraction of the cost because they're not recouping billions in R&D investment or spending millions on advertising.
Do I need a prescription for compounded semaglutide?
Yes, absolutely. Any legitimate compounding pharmacy requires a valid prescription from a licensed physician. Programs like Coreage Rx include the physician consultation as part of their service—the doctor reviews your medical history and writes the prescription if appropriate. Avoid any source that offers semaglutide without a prescription; that's illegal and dangerous.
Can I use insurance for compounded semaglutide?
Most insurance plans don't cover compounded medications. However, at $99-$549/month, compounded semaglutide is often cheaper than insurance copays for brand-name Wegovy (which can be $50-$200/month IF your insurance covers it for weight loss, which many don't). You also avoid prior authorization hassles and coverage restrictions.
Which is better: 503A or 503B pharmacy?
503B pharmacies are better. They have FDA registration, regular inspections, must follow Current Good Manufacturing Practices (CGMP), and have more stringent quality testing. 503A pharmacies are state-licensed with less oversight. If you're comparing two options at the same price, always choose 503B. Even better: Coreage Rx offers 503B quality at a lower price than most 503A options.
How long do I need to take semaglutide?
Most people take semaglutide for at least 12-18 months to achieve their weight loss goals and maintain results. Clinical trials showed optimal results at 68 weeks (about 16 months). Some people continue long-term for weight maintenance at a lower dose. Your prescribing physician will help you determine the right duration based on your goals and progress. This is why choosing an affordable option like Coreage Rx matters—you'll save thousands over the treatment duration.
Final Recommendation
After comparing all major compounding pharmacy options for semaglutide, my recommendation is straightforward: choose Coreage Rx.
At $99/month with a 503B FDA-registered pharmacy, you get the highest quality compounded semaglutide at the lowest price. You're not sacrificing quality for cost—you're getting better pharmacy oversight than Hims or Ro while saving $150/month.
The medication is chemically identical across all options. The difference is pharmacy oversight level and price. Coreage Rx wins on both factors.
If you want an alternative, Henry Meds ($297/month, 503B) is also excellent. I'd avoid paying $399+ unless you specifically need extensive coaching—the core medical treatment is the same everywhere.
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Medical Disclaimer: This article is for informational purposes only and not medical advice. Consult with a licensed healthcare provider before starting any weight loss medication. Read our full medical disclaimer.