Best Online Tirzepatide Program 2026: Complete Comparison Guide
Looking for online access to tirzepatide (Mounjaro/Zepbound)? I've compared all major telehealth programs offering physician-supervised tirzepatide for weight loss. Here's what you need to know about pricing, quality, and finding the most affordable option in 2026.
Quick Answer
The best online tirzepatide program for most people is Coreage Rx at $99/month. You get physician-supervised treatment with compounded tirzepatide from an FDA-registered 503B pharmacy, the same active ingredient as Mounjaro and Zepbound. The medication is identical—you're just avoiding the brand-name markup that can cost $1,000+ per month.
Read my full Coreage Rx review for details on my personal experience.
Why Choose an Online Tirzepatide Program?
Tirzepatide (the active ingredient in Mounjaro and Zepbound) is currently the most effective weight loss medication available, with clinical trials showing 15-22% total body weight loss over 72 weeks. That's significantly better than semaglutide (10-15%). But the brand-name versions cost $1,000-$1,400 per month without insurance.
Online telehealth programs changed everything by offering compounded tirzepatide—the same medication from FDA-registered pharmacies—for a fraction of the cost. Here's what makes these programs worth considering:
- Massive cost savings: $99-$549/month vs $1,000-$1,400 for brand-name
- Same medication: Compounded tirzepatide is identical to Mounjaro/Zepbound
- Best results available: Tirzepatide shows superior weight loss vs other GLP-1s
- Physician supervised: Licensed doctors review your health and prescribe
- Delivered to your door: No pharmacy visits or insurance battles
- Ongoing support: Most programs include regular check-ins and monitoring
Best Online Tirzepatide Programs Compared
I've researched and compared the major online tirzepatide programs. Here's my honest assessment based on pricing, quality, physician oversight, and customer experience.
| Program | Monthly Cost | Pharmacy Type | Best For |
|---|---|---|---|
| Coreage Rx | $99 | 503B FDA-registered | Best value & quality |
| Henry Meds | $297 | 503B FDA-registered | Good alternative |
| Mochi Health | $399 | 503B FDA-registered | Premium experience |
| Hims & Hers | $399 | 503A compounding | Brand recognition |
| Ro | $399 | 503A compounding | Established platform |
| Strut Health | $549 | 503A compounding | Comprehensive support |
#1 Best Overall: Coreage Rx ($99/month)
Coreage Rx
Why I recommend it: Coreage Rx offers the best combination of price, quality, and physician supervision. At $99/month, you get compounded tirzepatide from a 503B FDA-registered pharmacy—the same medication as Mounjaro/Zepbound at 93% less cost.
Pros:
- Lowest price: $99/month all-inclusive
- 503B FDA-registered pharmacy (highest quality tier)
- Licensed physician consultation included
- Access to most effective weight loss medication
- Home delivery with discreet packaging
- No insurance needed or insurance headaches
- Ongoing medical monitoring and support
Cons:
- Newer company (less brand recognition)
- Limited additional wellness features
- Fewer marketing resources than competitors
My experience: I've been using Coreage Rx for my tirzepatide treatment and the results have been exceptional. The physician consultation was thorough, the medication arrived quickly, and I've experienced steady weight loss without major side effects. Read my full Coreage Rx review.
Other Quality Options
Henry Meds - $297/month
Henry Meds is a solid alternative at $297/month. They use 503B FDA-registered pharmacies and have excellent customer service. The extra $48/month gets you a slightly more polished onboarding experience and faster customer support responses.
Best for: Those who want a proven mid-tier option with responsive support
Mochi Health - $399/month
Mochi Health positions itself as a premium option with health coaching and nutrition guidance. They also use 503B pharmacies, so the medication quality is identical to cheaper options. You're paying $150/month more for the coaching and app experience.
Best for: Those who want coaching and don't mind paying extra for premium support
Hims & Hers - $399/month
Hims & Hers is a well-known brand with heavy marketing. They use 503A compounding pharmacies (a step below 503B in terms of oversight and scale). At $399/month, you're paying significantly more for brand recognition without getting higher-quality medication.
Best for: Those who prioritize brand familiarity over cost savings
Ro - $399/month
Ro has been around since 2017 and offers a clean user experience. Like Hims, they use 503A compounding pharmacies. The medication is fine, but you're paying $150/month extra compared to Coreage Rx for essentially the same treatment with a nicer app interface.
Best for: Those who value an established company with a polished digital experience
Strut Health - $549/month
Strut Health is the most expensive option on this list at $549/month. They offer comprehensive support and use 503A compounding pharmacies. Unless you need extensive hand-holding, it's hard to justify paying $300/month more than Coreage Rx for the same medication.
Best for: Those who want maximum support and aren't price-sensitive
Understanding 503A vs 503B Pharmacies
Not all compounded tirzepatide is created equal. The key difference is whether it comes from a 503A or 503B pharmacy:
503B FDA-Registered
- Registered with and inspected by FDA
- Can produce larger batches for broader distribution
- Higher quality standards and oversight
- Must follow Current Good Manufacturing Practices (CGMP)
- More stringent testing requirements
Used by: Coreage Rx, Henry Meds, Mochi Health
503A Compounding
- State-licensed compounding pharmacies
- Can only compound for individual prescriptions
- Less FDA oversight and inspection
- Lower production volume requirements
- Variable quality between pharmacies
Used by: Hims & Hers, Ro, Strut Health
Bottom line: 503B pharmacies have higher oversight and quality standards. If two programs cost the same, choose the one using a 503B pharmacy. If you're comparing Coreage Rx ($99, 503B) to Hims ($399, 503A), you're getting better quality at a lower price with Coreage Rx.
Tirzepatide vs Semaglutide: Which Is Better?
A common question: should you choose tirzepatide or semaglutide? Here's the data-driven answer:
Clinical Results Comparison:
Tirzepatide (Mounjaro/Zepbound)
- Weight loss: 15-22% total body weight
- Mechanism: Dual GIP/GLP-1 receptor agonist
- Trial: SURMOUNT-1 (72 weeks)
- Side effects: Moderate GI symptoms
- Cost (compounded): $99-$549/month
Semaglutide (Ozempic/Wegovy)
- Weight loss: 10-15% total body weight
- Mechanism: GLP-1 receptor agonist only
- Trial: STEP trials (68 weeks)
- Side effects: Moderate GI symptoms
- Cost (compounded): $99-$549/month
My recommendation: Since compounded versions cost the same, start with tirzepatide. You get superior weight loss results (up to 22% vs 15%) with the same cost and similar side effect profile. Read my full comparison: Best GLP-1 for Weight Loss.
What's Included in These Programs?
Most online tirzepatide programs include similar core services:
- Physician consultation: Licensed doctor reviews your medical history and determines if tirzepatide is appropriate for you
- Prescription medication: Compounded tirzepatide (same active ingredient as Mounjaro/Zepbound) shipped monthly to your door
- Injection supplies: Pre-filled syringes or vials with needles, alcohol swabs, and sharps container
- Dosing guidance: Instructions on proper injection technique and titration schedule (starting at 2.5mg and gradually increasing to 5mg, 7.5mg, 10mg, 12.5mg, or 15mg)
- Ongoing monitoring: Regular check-ins with medical team to track progress and adjust dosage
- Customer support: Access to support team for questions about medication, side effects, or technical issues
Premium programs (Mochi Health, Strut Health) add nutrition coaching, meal planning, and more frequent check-ins. But the core medical treatment—physician oversight and compounded tirzepatide—is essentially the same across all programs.
Cost Comparison: Online vs Traditional
Let's break down what you'd pay for different tirzepatide options over one year:
| Option | Monthly Cost | Annual Cost | Savings vs Brand |
|---|---|---|---|
| Zepbound (brand, no insurance) | $1,349 | $16,188 | — |
| Mounjaro (brand, no insurance) | $1,023 | $12,276 | — |
| Coreage Rx (compounded) | $99 | $1,188 | Save $11,088 - $13,200 |
| Henry Meds (compounded) | $297 | $3,564 | Save $8,712 - $15,000 |
| Hims/Ro (compounded) | $399 | $4,788 | Save $7,488 - $11,400 |
Even the most expensive compounded option (Strut Health at $549/month = $6,588/year) saves you $5,688-$9,600 annually compared to brand-name versions. With Coreage Rx, you save over $13,000 per year compared to Zepbound.
Who Qualifies for Online Tirzepatide?
To qualify for tirzepatide through online programs, you typically need to meet these criteria:
Qualification Requirements:
- BMI of 30+ (obese), OR BMI of 27+ with a weight-related health condition
- Age 18+ (most programs don't treat minors)
- No contraindications (personal or family history of medullary thyroid carcinoma, MEN 2, etc.)
- Not pregnant or planning to become pregnant
- No current use of other GLP-1 medications
Weight-related health conditions that may qualify you at BMI 27+ include: type 2 diabetes, high blood pressure, high cholesterol, sleep apnea, or cardiovascular disease. The physician consultation will determine if tirzepatide is medically appropriate for your situation.
How to Get Started
Getting started with an online tirzepatide program is straightforward:
- Complete online intake: Fill out a medical questionnaire about your health history, current medications, and weight loss goals (10-15 minutes)
- Physician review: A licensed doctor reviews your information and determines if tirzepatide is appropriate. Most programs approve within 24-48 hours
- Prescription sent to pharmacy: If approved, your prescription is sent to the compounding pharmacy
- Medication shipped: Your first month's supply ships to your door (usually arrives in 3-7 days)
- Start treatment: Follow the dosing instructions and inject once weekly, same day each week. Start at 2.5mg for the first 4 weeks
- Ongoing monitoring: Check in regularly with your medical team, increase dosage every 4 weeks as tolerated, and track your progress
Ready to Get Started?
Start with Coreage Rx for the best combination of price ($99/month), quality (503B pharmacy), and access to the most effective weight loss medication available.
Start Free Consultation →Frequently Asked Questions
Is compounded tirzepatide as effective as Mounjaro or Zepbound?
Yes. Compounded tirzepatide contains the same active ingredient (tirzepatide) at the same concentrations as brand-name Mounjaro and Zepbound. The medication is chemically identical and works the same way in your body. The difference is that compounded versions come from FDA-registered compounding pharmacies rather than Eli Lilly, which allows them to be sold at a fraction of the brand-name price.
Are online tirzepatide programs safe?
Yes, when you use a legitimate program with licensed physicians and FDA-registered pharmacies. Programs like Coreage Rx, Henry Meds, and others on this list all require physician oversight, source medication from regulated pharmacies, and provide ongoing medical monitoring. Avoid programs that don't require a prescription, source medication from overseas, or lack proper medical supervision.
Why is tirzepatide more effective than semaglutide?
Tirzepatide is a dual GIP/GLP-1 receptor agonist, while semaglutide only targets GLP-1 receptors. The additional GIP component enhances insulin secretion and appears to amplify weight loss effects. Clinical trials show tirzepatide produces 15-22% weight loss vs 10-15% for semaglutide. Since compounded versions cost the same, tirzepatide offers better results for the same price.
Can I use insurance for online tirzepatide programs?
Most insurance doesn't cover compounded tirzepatide from online programs. However, at $99-$549/month, these programs are often cheaper than insurance copays for brand-name Zepbound (which can be $50-$200/month with insurance, if covered at all). Plus, you avoid prior authorization hassles and restrictive coverage requirements.
How much weight can I expect to lose?
Clinical trials of tirzepatide (SURMOUNT trials) showed participants lost an average of 15-22% of their total body weight over 72 weeks. At the highest dose (15mg), average weight loss was 22%. Individual results vary based on starting weight, diet, exercise, and adherence to treatment. The medication works by reducing appetite, slowing stomach emptying, and improving insulin sensitivity.
What are the side effects of tirzepatide?
The most common side effects are gastrointestinal: nausea, diarrhea, constipation, vomiting, and decreased appetite. These are usually mild to moderate and improve as your body adjusts. Starting at a low dose (2.5mg) and gradually increasing every 4 weeks helps minimize side effects. More serious but rare side effects include pancreatitis, gallbladder problems, and hypoglycemia (if combined with insulin or sulfonylureas). Your prescribing physician will discuss all risks and contraindications.
Final Recommendation
After comparing all major online tirzepatide programs, my recommendation is clear: start with Coreage Rx.
At $99/month with a 503B FDA-registered pharmacy, you get the best value without compromising on quality or medical oversight. The medication is identical to what you'd get from more expensive programs—you're just not paying for their marketing budgets.
If Coreage Rx doesn't work out for any reason, Henry Meds ($297/month) is an excellent alternative with similar quality standards. I'd avoid paying $399+ unless you specifically need the extra coaching and support offered by premium programs.
Tirzepatide represents the cutting edge of weight loss medication—superior results to semaglutide at the same compounded price. Don't let the $1,000+ monthly cost of brand-name Mounjaro or Zepbound stop you from accessing this highly effective treatment. Compounded tirzepatide offers the same results at a fraction of the price.
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Medical Disclaimer: This article is for informational purposes only and not medical advice. Consult with a licensed healthcare provider before starting any weight loss medication. Read our full medical disclaimer.